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Invitrogen
Defensin 5 Polyclonal Antibody
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Product Details
PA5-82540
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment of Human DEFA5 (Product #RP-89636).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ESLQERADEA TTQKQSGEDN QDLAISFAGN GLSALRTSGS QARATCYCRT GRCATRESLS GVCEISGRLY RLCCR
Highest antigen sequence indentity to the following orthologs: Rat - 49%, Mouse - 39%.
Target Information
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Defensin alpha 5; defensin, alpha 5, Paneth cell-specific; defensin, alpha 5, preproprotein; Defensin-5; HD5; HD5(20-94); MGC129728
Gene Aliases: DEF5; DEFA5; HD-5
UniProt ID: (Human) Q01523
Entrez Gene ID: (Human) 1670
immune system process
defense response
antibacterial humoral response
killing of cells of other organism
positive regulation of interleukin-8 production
defense response to bacterium
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
protein homotetramerization
membrane disruption in other organism
killing by host of symbiont cells
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of membrane permeability
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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