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Invitrogen
BST-2 Polyclonal Antibody
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Product Details
PA5-82572
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BST2. Recombinant protein control fragment (Product #RP-88681).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: THLLQQELTE AQKGFQDVEA QAATCNHTVM ALMASLDAEK AQGQKKVEEL EGEITTLNHK LQDASAEVER LRRENQVLSV RIADKKYYPS SQDSSSAAAP QLLIVLLG
Highest antigen sequence indentity to the following orthologs: Mouse - 29%, Rat - 29%.
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antiviral factor tetherin; Bone marrow stromal antigen 2; BST-2; CD317; HM1.24 antigen; NPC-A-7; PDCA-1; Tetherin; unnamed protein product
Gene Aliases: BST2; CD317; HM1.24; TETHERIN
UniProt ID: (Human) Q10589
Entrez Gene ID: (Human) 684
immune system process
negative regulation of plasmacytoid dendritic cell cytokine production
response to virus
negative regulation of cell growth
negative regulation of cell migration
regulation of actin cytoskeleton organization
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of viral genome replication
innate immune response
defense response to virus
positive regulation of leukocyte proliferation
negative regulation of intracellular transport of viral material
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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