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Invitrogen
Bi-1 Polyclonal Antibody
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Product Details
PA5-82588
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TMBIM6. Recombinant protein control fragment (Product #RP-91281).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MNIFDRKINF DALLKFSHIT PSTQQHLKK
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bax inhibitor 1; BI-1; TEGT; testis enhanced gene transcript; Testis-enhanced gene transcript protein; testis-enhanced gene transcript protein; integral membrane protein; Transmembrane BAX inhibitor motif-containing protein 6; unnamed protein product
Gene Aliases: BAXI1; BI-1; BI1; TEGT; TMBIM6
UniProt ID: (Human) P55061
Entrez Gene ID: (Human) 7009
negative regulation of transcription from RNA polymerase II promoter
negative regulation of immunoglobulin production
autophagy
apoptotic process
response to unfolded protein
negative regulation of calcium ion transport into cytosol
endoplasmic reticulum calcium ion homeostasis
negative regulation of RNA splicing
cellular response to unfolded protein
response to endoplasmic reticulum stress
neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
IRE1-mediated unfolded protein response
negative regulation of apoptotic process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
response to L-glutamate
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of IRE1-mediated unfolded protein response
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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