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Invitrogen
LIS1 Polyclonal Antibody
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Product Details
PA5-82710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PAFAH1B1. Recombinant protein control fragment (Product #RP-100462).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ADYLRSNGYE EAYSVFKKEA ELDVNEELDK KYAGLLEKKW TSVIRLQKKV MELESKLNEA KEEFTSGGPL GQKRDPKEWI PRPPEKYALS GHRSPVTRVI FHPVFSVMVS ASEDATIKVW DYETGDFERT LKGHTDSVQD ISFDHS
Highest antigen sequence indentity to the following orthologs: Rat - 99%, Mouse - 99%.
Target Information
VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LIS-1; lissencephaly 1 protein; Lissencephaly-1 protein; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; PHFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Platelet-activating factor acetylhydrolase IB subunit beta; RP23-194P5.2; unnamed protein product
Gene Aliases: LIS1; LIS2; MDCR; MDS; NudF; PAFAH; PAFAH1B1; PAFAHA
UniProt ID: (Human) P43034
Entrez Gene ID: (Human) 5048
establishment of mitotic spindle orientation
microtubule cytoskeleton organization
ameboidal-type cell migration
acrosome assembly
neuron migration
positive regulation of cytokine-mediated signaling pathway
lipid metabolic process
microtubule-based process
nuclear migration
JNK cascade
chemical synaptic transmission
germ cell development
nervous system development
neuroblast proliferation
learning or memory
retrograde axonal transport
adult locomotory behavior
protein secretion
negative regulation of neuron projection development
lipid catabolic process
cell migration
stem cell division
transmission of nerve impulse
corpus callosum morphogenesis
hippocampus development
layer formation in cerebral cortex
cerebral cortex neuron differentiation
cerebral cortex development
actin cytoskeleton organization
cell differentiation
forebrain development
microtubule organizing center organization
osteoclast development
reelin-mediated signaling pathway
positive regulation of embryonic development
establishment of planar polarity of embryonic epithelium
cortical microtubule organization
positive regulation of axon extension
positive regulation of mitotic cell cycle
negative regulation of JNK cascade
platelet activating factor metabolic process
vesicle transport along microtubule
brain morphogenesis
modulation of synaptic transmission
neuromuscular process controlling balance
microtubule sliding
nuclear envelope disassembly
positive regulation of cellular component organization
cell division
establishment of localization in cell
establishment of organelle localization
establishment of centrosome localization
maintenance of centrosome location
auditory receptor cell development
positive regulation of dendritic spine morphogenesis
regulation of microtubule cytoskeleton organization
cochlea development
microtubule cytoskeleton organization involved in establishment of planar polarity
myeloid leukocyte migration
regulation of postsynapse organization
radial glia-guided pyramidal neuron migration
interneuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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