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Invitrogen
Jagged1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82765
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human JAG1. Recombinant protein control fragment (Product #RP-93722).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LRKRRKPGSH THSASEDNTT NNVREQLNQI KNPIEKHGAN TVPIKDYENK NSKMSKIRTH NSEVEEDDMD KHQQKARFAK QPAYTLVDRE EKPPNGTPTK HPNWTNKQDN RDLESAQSLN RMEYI
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 94%.
Target Information
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: jagged canonical Notch ligand 1; jagged-1 protein; Notch ligand; putative; unnamed protein product
Gene Aliases: AGS; AGS1; AHD; AWS; CD339; CMT2HH; DCHE; HJ1; JAGL1
UniProt ID: (Human) P78504
Entrez Gene ID: (Human) 182
angiogenesis
cell fate determination
negative regulation of cell-matrix adhesion
T cell mediated immunity
aortic valve morphogenesis
pulmonary valve morphogenesis
cardiac right ventricle morphogenesis
cell communication
Notch signaling pathway
nervous system development
regulation of gene expression
negative regulation of cell-cell adhesion
hemopoiesis
keratinocyte differentiation
negative regulation of cell migration
response to muramyl dipeptide
aorta morphogenesis
regulation of cell proliferation
myoblast differentiation
endothelial cell differentiation
negative regulation of cell differentiation
negative regulation of endothelial cell differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
animal organ development
system development
inner ear development
cardiac septum morphogenesis
pulmonary artery morphogenesis
cardiac neural crest cell development involved in outflow tract morphogenesis
endocardial cushion cell development
positive regulation of cardiac epithelial to mesenchymal transition
nephron development
glomerular visceral epithelial cell development
distal tubule development
loop of Henle development
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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