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Product Details
PA5-82884
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CAPN2. Recombinant protein control fragment (Product #RP-88643).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ANLEEFDISE DDIDDGFRRL FAQLAGEDAE ISAFELQTIL RRVLAKRQDI KSDGFSIETC KIMVDMLDSD GSGKLGLKEF YILWTKIQKY QKIYREIDVD
Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 91%.
Target Information
Mu-Calpain, also known as Calpain-I, and m-calpain, also known as Calpain-II, are intracellular, calcium-dependent cysteine proteases. Mu-calpain has a micromolar sensitivity (thus the mu-) as compared to the millimolar calcium sensitivity of m-calpain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 80 kDa M-calpain subunit; Ca2-activated neutral protease subunit; Calcium-activated neutral proteinase 2; CALP80; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; Calpain large polypeptide L2; Calpain M-type; calpain, large polypeptide L2; Calpain-2 catalytic subunit; Calpain-2 large subunit; CANP 2; cysteine proteinase; M-calpain; m-calpain 80 kDa large subunit; m-calpain large subunit; Millimolar-calpain; unnamed protein product
Gene Aliases: AI326419; CANP2; CANPL2; CANPml; Capa-2; Capa2; CAPN2; m-calpain; m-calpin; mCANP
UniProt ID: (Human) P17655, (Mouse) O08529, (Rat) Q07009
Entrez Gene ID: (Human) 824, (Mouse) 12334, (Rat) 29154
calcium-dependent cysteine-type endopeptidase activity
calcium ion binding
protein binding
cytoskeletal protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
enzyme binding
macromolecular complex binding
metal ion binding
protein heterodimerization activity
cysteine protease
response to hypoxia
blastocyst development
proteolysis
myoblast fusion
female pregnancy
response to mechanical stimulus
positive regulation of cardiac muscle cell apoptotic process
protein autoprocessing
protein catabolic process
regulation of interleukin-6 production
cellular response to interferon-beta
response to hydrogen peroxide
behavioral response to pain
synaptic vesicle endocytosis
regulation of cytoskeleton organization
proteolysis involved in cellular protein catabolic process
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
vascular endothelial cell response to laminar fluid shear stress
vascular endothelial cell response to oscillatory fluid shear stress
protein catabolic process at postsynapse
positive regulation of myoblast fusion
positive regulation of phosphatidylcholine biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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