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Invitrogen
HDAC6 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82914
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HDAC6. Recombinant protein control fragment (Product #RP-92175).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QVHRRYWRSL RVMKVEDREG PSSSKLVTKK APQPAKPRLA ERMTTREKKV LEAGMGKVTS ASFGEESTPG QTNSETAVVA LTQDQPSEAA TGGATLAQTI SEAAIGGAML GQTTSEEAVG GATPDQTTSE ETVGGA
Highest antigen sequence indentity to the following orthologs: Mouse - 47%, Rat - 49%.
Target Information
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-tubulin deacetylase HDAC6; E3 ubiquitin-protein ligase HDAC6; FLJ16239; HDA6; HDAC6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6; unnamed protein product
Gene Aliases: CPBHM; HD6; JM21; KDAC6; PPP1R90
UniProt ID: (Human) Q9UBN7
Entrez Gene ID: (Human) 10013
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription corepressor binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
deacetylase activity
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
protein deacetylase activity
peroxidase inhibitor activity
ATPase inhibitor activity
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
ubiquitin binding
acetylspermidine deacetylase activity
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
ubiquitin protein ligase activity
dynein complex binding
protein deacetylation
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
response to stress
epidermal growth factor receptor signaling pathway
regulation of autophagy
positive regulation of epithelial cell migration
negative regulation of hydrogen peroxide metabolic process
macroautophagy
regulation of macroautophagy
protein ubiquitination
axonal transport of mitochondrion
negative regulation of protein complex assembly
regulation of protein stability
protein destabilization
lysosome localization
positive regulation of protein oligomerization
regulation of microtubule-based process
positive regulation of intracellular estrogen receptor signaling pathway
cellular response to heat
cellular response to topologically incorrect protein
negative regulation of protein complex disassembly
negative regulation of gene expression, epigenetic
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
negative regulation of cellular component organization
positive regulation of cellular component organization
mitochondrion localization
response to misfolded protein
cilium morphogenesis
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
cilium disassembly
parkin-mediated mitophagy in response to mitochondrial depolarization
cellular response to hydrogen peroxide
aggresome assembly
polyubiquitinated misfolded protein transport
tubulin deacetylation
macromolecule deacylation
regulation of mitophagy
positive regulation of type 2 mitophagy
negative regulation of aggrephagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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