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Invitrogen

HDAC6 Polyclonal Antibody

View all (47) HDAC6 antibodies

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HDAC6 Polyclonal Antibody

Product Details

PA5-82914

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human HDAC6. Recombinant protein control fragment (Product #RP-92175).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2790070

Product Specific Information

Immunogen sequence: QVHRRYWRSL RVMKVEDREG PSSSKLVTKK APQPAKPRLA ERMTTREKKV LEAGMGKVTS ASFGEESTPG QTNSETAVVA LTQDQPSEAA TGGATLAQTI SEAAIGGAML GQTTSEEAVG GATPDQTTSE ETVGGA

Highest antigen sequence indentity to the following orthologs: Mouse - 47%, Rat - 49%.

Target Information

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-tubulin deacetylase HDAC6; E3 ubiquitin-protein ligase HDAC6; FLJ16239; HDA6; HDAC6; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; Tubulin-lysine deacetylase HDAC6; unnamed protein product

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Gene Aliases: CPBHM; HD6; HDAC6; JM21; KDAC6; KIAA0901; PPP1R90

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UniProt ID: (Human) Q9UBN7

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Entrez Gene ID: (Human) 10013

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription corepressor binding actin binding histone deacetylase activity protein binding beta-catenin binding microtubule binding zinc ion binding transferase activity hydrolase activity deacetylase activity enzyme binding polyubiquitin binding ubiquitin protein ligase binding protein deacetylase activity peroxidase inhibitor activity ATPase inhibitor activity histone deacetylase binding tubulin deacetylase activity alpha-tubulin binding ubiquitin binding metal ion binding acetylspermidine deacetylase activity tau protein binding beta-tubulin binding misfolded protein binding Hsp90 protein binding dynein complex binding histone deacetylase activity, hydrolytic mechanism
Process(es)
protein polyubiquitination response to amphetamine chromatin organization protein deacetylation ubiquitin-dependent protein catabolic process misfolded or incompletely synthesized protein catabolic process intracellular protein transport autophagy response to stress actin filament organization negative regulation of microtubule depolymerization epidermal growth factor receptor signaling pathway regulation of autophagy positive regulation of epithelial cell migration negative regulation of hydrogen peroxide metabolic process regulation of mitochondrion organization negative regulation of neuron projection development macroautophagy regulation of macroautophagy axonal transport of mitochondrion neuron differentiation negative regulation of protein complex assembly regulation of protein stability protein destabilization lysosome localization positive regulation of protein oligomerization regulation of microtubule-based process protein-containing complex disassembly positive regulation of intracellular estrogen receptor signaling pathway cellular response to heat response to immobilization stress cellular response to topologically incorrect protein aggrephagy erythrocyte enucleation ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway negative regulation of protein complex disassembly regulation of fat cell differentiation negative regulation of gene expression, epigenetic negative regulation of proteolysis negative regulation of transcription, DNA-templated collateral sprouting negative regulation of axon extension involved in axon guidance positive regulation of dendrite morphogenesis negative regulation of cellular component organization positive regulation of cellular component organization response to corticosterone mitochondrion localization response to misfolded protein positive regulation of synaptic transmission, glutamatergic cilium morphogenesis regulation of microtubule-based movement regulation of androgen receptor signaling pathway dendritic spine morphogenesis cilium disassembly parkin-mediated mitophagy in response to mitochondrial depolarization regulation of biological quality regulation of establishment of protein localization cellular response to hydrogen peroxide regulation of microtubule cytoskeleton organization aggresome assembly polyubiquitinated misfolded protein transport protein targeting to vacuole involved in autophagy cellular response to misfolded protein cellular response to parathyroid hormone stimulus response to dexamethasone tubulin deacetylation macromolecule deacylation polyamine deacetylation spermidine deacetylation membraneless organelle assembly positive regulation of cellular response to oxidative stress regulation of mitophagy positive regulation of cholangiocyte proliferation positive regulation of type 2 mitophagy negative regulation of aggrephagy
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