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Invitrogen
CLIP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-82930
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CLIP1. Recombinant protein control fragment (Product #RP-92538).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KNLELQLKEN KRQLSSSSGN TDTQADEDER AQESQIDFLN SVIVDLQRKN QDLKMKVEMM SEAALNGNGD DLNNYDSDDQ EKQSKKKPRL FCDICDCFDL HDTEDCPTQA QMSEDPPHST HHGSRGEERP YCEICEMFGH WATNCNDDET
Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 97%.
Target Information
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Clip 170; contains an 11 amino acid insert in tandem with a 35 amino acid insert found in restin; contains an 11 amino acid insert instead of the 35 amino acid insert found in restin; cytoplasmic linker protein; cytoplasmic linker protein 1; cytoplasmic linker protein 170; cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein 50; cytoplasmic linker protein CLIP-170; MGC131604; Reed-Steinberg cell-espressed intermediate filament-associated protein; Reed-Steinberg cell-expressed intermediate filament-associated protein; restin (Reed-Steinberg cell-espressed intermediate filament-associated protein); restin (Reed-Steinberg cell-expressed intermediate filament-associated protein); unnamed protein product
Gene Aliases: 1110007I12Rik; 4631429H07Rik; CLIP; CLIP-170; CLIP170; Clip50; CYLN1; mKIAA4046; restin; RSN
UniProt ID: (Human) P30622, (Rat) Q9JK25, (Mouse) Q922J3
Entrez Gene ID: (Human) 6249, (Rat) 65201, (Mouse) 56430
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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