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Invitrogen
Spectrin alpha-1 Polyclonal Antibody
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Product Details
PA5-82997
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SPTA1. Recombinant protein control fragment (Product #RP-94435).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HQGIVPAVYV RRLAHDEFPM LPQRRREEPG NITQRQEQIE NQYRSLLDRA EERRRRLLQR YNEFLLAYEA GDMLEWIQEK KAENTGVEL
Highest antigen sequence indentity to the following orthologs: Rat - 85%, Mouse - 81%.
Target Information
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-I spectrin; elliptocytosis 2; erythrocyte alpha-spectrin; Erythroid alpha-spectrin; spectrin alpha chain, erythrocyte; Spectrin alpha chain, erythrocytic 1
Gene Aliases: EL2; HPP; HS3; SPH3; SPTA; SPTA1
UniProt ID: (Human) P02549
Entrez Gene ID: (Human) 6708
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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