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Invitrogen
MSH6 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-83010
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MSH6. Recombinant protein control fragment (Product #RP-95115).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MVENECEDPS QETITFLYKF IKGACPKSYG FNAARLANLP EEVIQKGHRK AREFEKMNQS LRLFREVCLA SERSTV
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 95%.
Target Information
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage, and may promote apoptosis in normal cells, thus protecting mammals from ultraviolet-induced malignant transformation and hence the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G/T mismatch binding protein homolog; G/T mismatch-binding protein; mutS (E. coli) homolog 6; MutS alpha 160kDa subunit; mutS protein homolog 6; mutS-alpha 160 kDa subunit; MutS-alpha 160kDa subunit; mutS-like protein 6; p160; probable G/T mismatch binding protein; homolog of bacterial MutS proteins; rCG61559-like; Sperm associated protein; sperm-associated protein; unnamed protein product
Gene Aliases: GTBP; GTMBP; HNPCC5; HSAP; LYNCH5; MMRCS3; MSH-6; p160
UniProt ID: (Human) P52701, (Mouse) P54276
Entrez Gene ID: (Human) 2956, (Mouse) 17688, (Rat) 100360342
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
enzyme binding
mismatched DNA binding
guanine/thymine mispair binding
single guanine insertion binding
single thymine insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
histone H3K36me3 reader activity
ATP-dependent DNA damage sensor activity
meiotic mismatch repair
DNA repair
mismatch repair
chromatin organization
spermatogenesis
determination of adult lifespan
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
intrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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