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Invitrogen
WRN Polyclonal Antibody
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Product Details
PA5-83025
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WRN. Recombinant protein control fragment (Product #RP-89491).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KADIRQVIHY GAPKDMESYY QEIGRAGRDG LQSSCHVLWA PADINLNRHL LTEIRNEKFR LYKLKMMAKM EKYLHSSRCR RQIILSHFED KQVQKASLGI MGTEKCCDNC RSRLDHCYSM DDSEDTSWDF GPQAFKLLSA VD
Highest antigen sequence indentity to the following orthologs: Rat - 82%, Mouse - 82%.
Target Information
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; DKFZp686C2056; DNA helicase, RecQ-like type 3; exonuclease WRN; RecQ protein-like 2; Werner syndrome ATP-dependent helicase; Werner syndrome protein; Werner syndrome RecQ like helicase; Werner syndrome, RecQ helicase-like; WRN
Gene Aliases: RECQ3; RECQL2; RECQL3; WRN
UniProt ID: (Human) Q14191
Entrez Gene ID: (Human) 7486
nucleotide binding
magnesium ion binding
four-way junction DNA binding
Y-form DNA binding
bubble DNA binding
nucleic acid binding
DNA binding
DNA helicase activity
catalytic activity
helicase activity
nuclease activity
exonuclease activity
protein binding
ATP binding
3'-5' exonuclease activity
four-way junction helicase activity
hydrolase activity
isomerase activity
ATPase activity
manganese ion binding
MutLalpha complex binding
protein homodimerization activity
3'-5' DNA helicase activity
macromolecular complex binding
metal ion binding
G-quadruplex DNA binding
forked DNA-dependent helicase activity
telomeric D-loop binding
telomeric G-quadruplex DNA binding
3'-flap-structured DNA binding
catalytic activity, acting on DNA
8-hydroxy-2'-deoxyguanosine DNA binding
telomere maintenance
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
nucleobase-containing compound metabolic process
DNA metabolic process
DNA replication
DNA repair
base-excision repair
mismatch repair
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
response to oxidative stress
determination of adult lifespan
cellular response to starvation
response to UV-C
replication fork processing
telomere maintenance via semi-conservative replication
DNA geometric change
regulation of growth rate
positive regulation of hydrolase activity
telomeric D-loop disassembly
cellular response to gamma radiation
cellular senescence
replicative senescence
t-circle formation
positive regulation of strand invasion
protein localization to nucleolus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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