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Invitrogen
FBXO5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-83055
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FBXO5. Recombinant protein control fragment (Product #RP-94668).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EENFGDSLQS CLLQIQSPDQ YPNKNLLPVL HFEKVVCSTL KKNAKRNPKV DREMLKEIIA RGNFRLQNII GRKMGLECVD ILSELFRRGL R
Highest antigen sequence indentity to the following orthologs: Mouse - 77%, Rat - 72%.
Target Information
F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: early fission inhibitory protein 1; early mitotic inhibitor 1; F-box protein Fbx5; unnamed protein product
Gene Aliases: EMI1; FBX5; Fbxo31
UniProt ID: (Human) Q9UKT4
Entrez Gene ID: (Human) 26271
regulation of DNA replication
cellular response to DNA damage stimulus
regulation of mitotic nuclear division
regulation of mitotic cell cycle
positive regulation of cell proliferation
negative regulation of cell cycle process
positive regulation of G2/M transition of mitotic cell cycle
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
negative regulation of DNA endoreduplication
positive regulation of osteoblast differentiation
negative regulation of meiotic nuclear division
negative regulation of mitotic metaphase/anaphase transition
negative regulation of ubiquitin-protein transferase activity
positive regulation of biomineral tissue development
negative regulation of ubiquitin protein ligase activity
positive regulation of mesenchymal stem cell migration
negative regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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