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Invitrogen
ITM2B Polyclonal Antibody
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Product Details
PA5-83079
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ITM2B. Recombinant protein control fragment (Product #RP-102188).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YFALQPDDVY YCGIKYIKDD VILNEPSADA PAALYQTIEE NIKIFEEEEV EFISVPVPEF ADSDPANIVH DFNKKLTAYL DLNLDKCYVI PLNTSIVMPP RNLLELLINI KAGTYLPQSY LIHEHMVITD RIENIDHLGF FIYRLCH
Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 96%.
Target Information
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABri/ADan amyloid peptide; Bri; BRICHOS domain containing 2B; epididymis secretory sperm binding protein; imBRI2; Immature BRI2; Integral membrane protein 2B; OTTHUMP00000018394; Protein E25B; RP11-196P14.1; Transmembrane protein BRI; unnamed protein product
Gene Aliases: ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2; ITM2B; RDGCA
UniProt ID: (Human) Q9Y287
Entrez Gene ID: (Human) 9445
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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