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Invitrogen
TSC2 Polyclonal Antibody
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Product Details
PA5-83141
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TSC2. Recombinant protein control fragment (Product #RP-95482).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SVLPSFYQAM ACPNEVVSYE IVLSITRLIK KYRKELQVVA WDILLNIIER LLQQLQTLDS PELRTIVHDL LTTVEELCDQ NEFHGSQE
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 93%.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000198394; protein phosphatase 1, regulatory subunit 160; Tuberin; Tuberous sclerosis 2 protein; tuberous sclerosis complex locus 2; unnamed protein product
Gene Aliases: LAM; PPP1R160; TSC2; TSC4
UniProt ID: (Human) P49815
Entrez Gene ID: (Human) 7249
neural tube closure
cytoplasmic translation
protein import into nucleus
endocytosis
heart development
protein localization
negative regulation of cell proliferation
cellular response to starvation
vesicle-mediated transport
positive regulation of macroautophagy
regulation of macroautophagy
regulation of endocytosis
negative regulation of Wnt signaling pathway
cellular response to nutrient levels
negative regulation of TOR signaling
TORC1 signaling
anoikis
negative regulation of translational initiation
positive regulation of translational initiation
regulation of insulin receptor signaling pathway
negative regulation of insulin receptor signaling pathway
positive chemotaxis
regulation of small GTPase mediated signal transduction
regulation of cell cycle
negative regulation of protein kinase B signaling
negative regulation of macromitophagy
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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