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Invitrogen
HDAC5 Polyclonal Antibody
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Product Details
PA5-83172
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HDAC5. Recombinant protein control fragment (Product #RP-95274).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: THPEETEEEL TEQQEVLLGE GALTMPREGS TESESTQEDL EEEDEEDDGE EEEDCIQVKD EEGESGAEEG PDLEEPGAGY KKLFSDAQP
Highest antigen sequence indentity to the following orthologs: Mouse - 85%, Rat - 84%.
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antigen NY-CO-9; DKFZp779K1053; FLJ90614; HD5; HD7; HD7b; HD9; HDAC; HDAC-5; HDAC5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 5; KIAA0744; putative Type II integral membrane protein; unnamed protein product
Gene Aliases: HD5; HDAC5; KIAA0600; NY-CO-9
UniProt ID: (Human) Q9UQL6
Entrez Gene ID: (Human) 10014
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcription corepressor binding
chromatin binding
histone deacetylase activity
protein kinase C binding
protein binding
hydrolase activity
protein deacetylase activity
identical protein binding
histone deacetylase binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
inflammatory response
response to xenobiotic stimulus
negative regulation of macromolecule biosynthetic process
regulation of myotube differentiation
negative regulation of myotube differentiation
response to activity
neuron differentiation
B cell differentiation
cellular response to insulin stimulus
regulation of gene expression, epigenetic
B cell activation
response to cocaine
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to lipopolysaccharide
negative regulation of cell migration involved in sprouting angiogenesis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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