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Invitrogen
MCM2 Polyclonal Antibody
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Product Details
PA5-83194
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MCM2. Recombinant protein control fragment (Product #RP-95259).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RFDILCVVRD TVDPVQDEML ARFVVGSHVR HHPSNKEEEG LANGSAAEPA MPNTYGVEPL PQEVLKKYII YAKERVHPKL NQMDQD
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 91%.
Target Information
MCM2 (Mini chromosome maintenance protein 2) is involved in regulating DNA replication. MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. It is similar to members of the family of early S-phase proteins. MCM2 has been mapped to 3q21. From its localization, CDCL1 became a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell devision cycle-like 1; cyclin-like 1; DNA replication licensing factor MCM2; KIAA0030; MGC10606; minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance protein 2 homolog; Nuclear protein BM28; unnamed protein product
Gene Aliases: BM28; CCNL1; cdc19; CDCL1; D3S3194; DFNA70; KIAA0030; MCM2; MITOTIN
UniProt ID: (Human) P49736
Entrez Gene ID: (Human) 4171
nucleotide binding
DNA binding
DNA helicase activity
DNA replication origin binding
single-stranded DNA binding
helicase activity
protein binding
ATP binding
zinc ion binding
hydrolase activity
ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
enzyme binding
histone binding
3'-5' DNA helicase activity
metal ion binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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