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Invitrogen

ZC3H12A Polyclonal Antibody

View all (8) ZC3H12A antibodies

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ZC3H12A Polyclonal Antibody

Product Details

PA5-83216

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZC3H12A. Recombinant protein control fragment (Product #RP-102612).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2790372

Product Specific Information

Immunogen sequence: CTYGIKCRFF HPERPSCPQR SVADELRANA LLSPPRAPSK DKNGRRPSPS SQSSSLLTES EQCSLDGKKL GAQASPGSRQ EGLTQTYAPS GRSLAP

Highest antigen sequence indentity to the following orthologs: Rat - 73%, Mouse - 75%.

Target Information

ZC3H12A is an MCP1 -induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bifunctional endoribonuclease and deubiquitinase ZC3H12A; Endoribonuclease ZC3H12A; FLJ23231; MCP-1 induced protein 1; MCPIP1; MCP-1 treatment-induced protein; MCP-induced protein 1; MCPIP; transcription factor; Monocyte chemotactic protein-induced protein 1; Reg1; Regnase-1; ribonuclease ZC3H12A; RP3-423B22.1; unnamed protein product; Zinc finger CCCH domain-containing protein 12A

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Gene Aliases: dJ423B22.1; MCPIP; MCPIP-1; MCPIP1; Reg1; ZC3H12A

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UniProt ID: (Human) Q5D1E8

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Entrez Gene ID: (Human) 80149

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Function(s)
DNA binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding nuclease activity endonuclease activity endoribonuclease activity exoribonuclease activity ribonuclease activity thiol-dependent ubiquitin-specific protease activity protein binding zinc ion binding hydrolase activity miRNA binding RNA stem-loop binding mRNA 3'-UTR AU-rich region binding ribosome binding metal ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter nuclear-transcribed mRNA catabolic process, nonsense-mediated decay angiogenesis negative regulation of protein phosphorylation positive regulation of defense response to virus by host immune system process immune response-activating signal transduction mRNA catabolic process apoptotic process inflammatory response cellular response to DNA damage stimulus nervous system development regulation of gene expression positive regulation of autophagy miRNA catabolic process positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of gene expression negative regulation of muscle cell apoptotic process positive regulation of lipid storage protein deubiquitination cell differentiation negative regulation of interferon-gamma production negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production cellular response to oxidative stress cellular response to glucose starvation positive regulation of protein import into nucleus negative regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral genome replication negative regulation of nitric oxide biosynthetic process positive regulation of fat cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter T cell receptor signaling pathway protein oligomerization defense response to virus negative regulation of cardiac muscle contraction positive regulation of mRNA catabolic process 3'-UTR-mediated mRNA destabilization cellular response to lipopolysaccharide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to virus negative regulation of cytokine production involved in inflammatory response positive regulation of execution phase of apoptosis positive regulation of p38MAPK cascade negative regulation of NIK/NF-kappaB signaling positive regulation of protein deubiquitination cellular response to sodium arsenite cellular response to ionomycin cellular response to chemokine negative regulation of T-helper 17 cell differentiation positive regulation of reactive oxygen species metabolic process positive regulation of miRNA catabolic process
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