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Invitrogen
EHHADH Polyclonal Antibody
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Product Details
PA5-83334
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EHHADH. Recombinant protein control fragment (Product #RP-96322).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TSGRRILADE ALKLGILDKV VNSDPVEEAI RFAQRVSDQP LESRRLCNKP IQSLPNMDSI FSEALLKMRR QHPGCLAQEA CVRAVQAAVQ YPYEVG
Highest antigen sequence indentity to the following orthologs: Rat - 66%, Mouse - 68%.
Target Information
As an L-hydroxy-specific enzyme, EHHADH (enoyl-CoA-hydratase:3-hydroxyacyl-CoA dehydrogenase), also known as Peroxisomal L-bifunctional enzyme, is a 723 amino acid protein has an essential tripeptide sequence on its carboxyl-terminus that is required for peroxisomal transport. EHHADH-null mice only exhibit a blunted peroxisome proliferative response when challenged with a peroxisome proliferator. Since there were no observed changes in lipid metabolism, this evidence suggests that enoyl-CoAs were diverted to the D-hydroxy-specific beta-oxidation system for metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3,2-trans-enoyl-CoA isomerase; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; L-3-hydroxyacyl-CoA dehydrogenase; L-bifunctional protein; L-bifunctional protein, peroxisomal; LBP; MFE1; Multifunctional enzyme 1; PBE; Peroxisomal bifunctional enzyme; peroxisomal enoyl-CoA hydratase; unnamed protein product
Gene Aliases: ECHD; EHHADH; FRTS3; L-PBE; LBFP; LBP; MFE1; PBFE
UniProt ID: (Human) Q08426
Entrez Gene ID: (Human) 1962
catalytic activity
3-hydroxyacyl-CoA dehydrogenase activity
dodecenoyl-CoA delta-isomerase activity
enoyl-CoA hydratase activity
protein binding
oxidoreductase activity
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
lyase activity
isomerase activity
intramolecular oxidoreductase activity, transposing C=C bonds
3-hydroxyacyl-CoA dehydratase activity
enzyme binding
NAD+ binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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