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Invitrogen
Neurocan Polyclonal Antibody
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Product Details
PA5-83354
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NCAN. Recombinant protein control fragment (Product #RP-95631).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TDASERGLHM QKLGSGSVQA ALAELVALPC LFTLQPRPSA ARDAPRIKWT KVRTASGQRQ DLPILVAKDN VVRVAKSWQG R
Highest antigen sequence indentity to the following orthologs: Mouse - 81%, Rat - 80%.
Target Information
Neurocan is a gene encoding a large chondroitin sulfate proteoglycan, predominantly expressed in the central nervous system. Located on chromosome 19 in humans, neurocan is part of the lectican family of proteoglycans, integral to the extracellular matrix where they modulate neuronal cell adhesion and migration. This proteoglycan is essential in the formation of the neural network during development and in maintaining the plasticity of the extracellular matrix in adult brains. Neurocan undergoes proteolytic processing, resulting in various fragments that influence neuronal growth and synapse stabilization. Altered neurocan expression has been linked to several neurological conditions such as schizophrenia, bipolar disorder, and Alzheimer's disease, likely due to its role in synaptic function and integrity of the neural matrix. Understanding neurocan's exact roles in neurological health and disease could illuminate pathways for potential therapeutic interventions targeting matrix remodeling and neuronal connectivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chondroitin sulfate proteoglycan 3; chondroitin sulfate proteoglycan 3 (neurocan); Neurocan core protein; neurocan proteoglycan
Gene Aliases: CSPG3; NCAN; NEUR
UniProt ID: (Human) O14594
Entrez Gene ID: (Human) 1463
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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