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Invitrogen
SNX2 Polyclonal Antibody
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Product Details
PA5-83367
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SNX2. Recombinant protein control fragment (Product #
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Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ATEEVSLDSP EREPILSSEP SPAVTPVTPT TLIAPRIESK SMSAPVIFDR SREEIEEEAN GDIFDIEIGV SDP
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.
Target Information
Sorting nexin 2 (SNX2) is a gene located on human chromosome 5q23.3 that encodes a protein involved in various cellular processes, primarily associated with endosomal sorting and intracellular trafficking. SNX2, along with SNX1, forms part of the sorting nexin family characterized by the presence of a Phox (PX) domain, which binds phosphoinositides and facilitates the interaction with membrane compartments such as endosomes. Functionally, SNX2 plays roles in the retrograde transport of Shiga toxin from endosomes to the Golgi apparatus, as well as regulation of endosome-endoplasmic reticulum contact sites through interaction with VAP proteins at the ER membrane. Additionally, SNX2 is implicated in autophagy initiation during nutrient starvation by facilitating the tubulation of early endosomes toward ER sites. As a membrane-associated protein, SNX2 is essential for protein trafficking and retrieval of transmembrane proteins, thus contributing to cellular homeostasis and the dynamic remodeling of endosomal zones.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTB-36H16.2; MGC5204; Sorting nexin-2; Transformation-related gene 9 protein; TRG-9
Gene Aliases: SNX2; TRG-9; TRG9
UniProt ID: (Human) O60749
Entrez Gene ID: (Human) 6643
epidermal growth factor receptor binding
insulin receptor binding
protein binding
phosphatidylinositol binding
protein homodimerization activity
protein heterodimerization activity
cadherin binding involved in cell-cell adhesion
transferrin receptor binding
leptin receptor binding
scaffold/adaptor protein
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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