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Invitrogen
BCR Polyclonal Antibody
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Product Details
PA5-83413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BCR. Recombinant protein control fragment (Product #RP-96534).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VDPVGFAEAW KAQFPDSEPP RMELRSVGDI EQELERCKAS IRRLEQEVNQ ERFRMIYLQT LLAKEKKSYD RQRW
Highest antigen sequence indentity to the following orthologs: Rat - 28%, Mouse - 97%.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABL; bcr; BCR protein; BCR, RhoGEF and GTPase activating protein; bcr/abl; bcr/able fusion protein; BCR/FGFR1 chimera protein; breakpoint cluster region; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; p150; protein kinase; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; unnamed protein product; v-abl
Gene Aliases: ALL; BCR; BCR1; CML; D22S11; D22S662; PHL
UniProt ID: (Human) P11274
Entrez Gene ID: (Human) 613
negative regulation of cellular extravasation
renal system process
protein phosphorylation
phagocytosis
signal transduction
small GTPase mediated signal transduction
brain development
cell migration
actin cytoskeleton organization
keratinocyte differentiation
response to lipopolysaccharide
regulation of Rho protein signal transduction
intracellular signal transduction
inner ear morphogenesis
regulation of vascular permeability
neutrophil degranulation
negative regulation of neutrophil degranulation
focal adhesion assembly
homeostasis of number of cells
negative regulation of inflammatory response
positive regulation of phagocytosis
modulation of synaptic transmission
neuromuscular process controlling balance
regulation of small GTPase mediated signal transduction
establishment of localization in cell
regulation of cell cycle
definitive hemopoiesis
negative regulation of respiratory burst
negative regulation of blood vessel remodeling
intracellular protein transmembrane transport
cellular response to lipopolysaccharide
activation of GTPase activity
macrophage migration
negative regulation of macrophage migration
negative regulation of reactive oxygen species metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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