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Invitrogen
RISC Polyclonal Antibody
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Product Details
PA5-83448
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SCPEP1. Recombinant protein control fragment (Product #RP-93236).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KPVISIVDEL LEAGINVTVY NGQLDLIVDT MGQEAWVRKL KWPELPKFSQ LKWKALYSDP KSLETSAFVK SYKNLAFYWI LKAGHMVPSD QGDMALKMMR LVTQQ
Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 85%.
Target Information
The RNA-induced silencing complex (RISC) is a key player in the regulation of gene expression through RNA interference (RNAi) mechanisms. It operates by utilizing small RNA molecules-such as microRNAs (miRNAs), small interfering RNAs (siRNAs), and PIWI-interacting RNAs (piRNAs)-which are processed from double-stranded RNA precursors by enzymes like Drosha and Dicer in animals, and DICER-LIKE in plants. RISC is a versatile molecular complex consisting of Argonaute proteins as its core component, which guides the complex to the target RNA by complementary base pairing. Once assembled, RISC can recruit other proteins that mediate gene silencing by degrading or inhibiting the translation of the target RNA. This post-transcriptional regulation system is integral to numerous biological processes, allowing cells to control gene expression finely and respond to endogenous and exogenous signals. The functionality of RISC in gene silencing highlights its significance in the broader context of genetic regulation and has implications in therapies that target gene expression through RNAi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: retinoid inducible serine carboxypeptidase; Retinoid-inducible serine carboxypeptidase; retinoid-inducible serine caroboxypeptidase; retinoid-inducible serine caroboxypetidase; Serine carboxypeptidase 1; serine carboxypeptidase 1 precursor protein; serine caroboxypeptidase 1
Gene Aliases: 2410018F01Rik; 4833411K15Rik; AI957256; HSCP1; MSTP034; RISC; SCP1; SCPEP1; UNQ265/PRO302
UniProt ID: (Human) Q9HB40, (Mouse) Q920A5, (Rat) Q920A6
Entrez Gene ID: (Human) 59342, (Mouse) 74617, (Rat) 114861
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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