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Invitrogen
PMCA4 ATPase Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-83500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ATP2B4. Recombinant protein control fragment (Product #RP-95778).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: THPEFAIEEE LPRTPLLDEE EEENPDKASK FGTRVLLLDG EVTPYANTNN NAVDCNQVQL PQSDSSLQSL ETSV
Highest antigen sequence indentity to the following orthologs: Rat - 46%, Mouse - 53%.
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin (Cat. # MA3-917 and MA3-918).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, Ca++ transporting, plasma membrane 4; matrix-remodeling-associated protein 1; plasma membrane calcium-ATPase isoform 4 alternative splice variant x at splice site A; plasma membrane calcium-ATPase isoform 4, splice variant b at alternative splice site C; sarcolemmal calcium pump; unnamed protein product
Gene Aliases: ATP2B2; MXRA1; PMCA4; PMCA4b; PMCA4x
UniProt ID: (Human) P23634
Entrez Gene ID: (Human) 493
nucleotide binding
calcium-transporting ATPase activity
protein binding
calmodulin binding
ATP binding
calcium ion transmembrane transporter activity
ATPase activity
sodium channel regulator activity
protein kinase binding
PDZ domain binding
protein phosphatase 2B binding
nitric-oxide synthase inhibitor activity
nitric-oxide synthase binding
scaffold protein binding
neural retina development
regulation of transcription from RNA polymerase II promoter
calcium ion transport
cellular calcium ion homeostasis
spermatogenesis
negative regulation of gene expression
urinary bladder smooth muscle contraction
negative regulation of angiogenesis
hippocampus development
sperm motility
ion transmembrane transport
nitric oxide-cGMP-mediated signaling pathway
negative regulation of blood vessel endothelial cell migration
negative regulation of nitric oxide biosynthetic process
regulation of cytosolic calcium ion concentration
response to hydrostatic pressure
calcium ion transmembrane transport
negative regulation of calcineurin-NFAT signaling cascade
cellular response to epinephrine stimulus
negative regulation of adrenergic receptor signaling pathway
calcium ion transmembrane import into cytosol
calcium ion import across plasma membrane
negative regulation of the force of heart contraction
transport across blood-brain barrier
negative regulation of arginine catabolic process
calcium ion export
regulation of sodium ion transmembrane transport
negative regulation of cellular response to vascular endothelial growth factor stimulus
regulation of cell cycle G1/S phase transition
positive regulation of protein localization to plasma membrane
negative regulation of cardiac muscle hypertrophy in response to stress
negative regulation of citrulline biosynthetic process
regulation of cardiac conduction
cellular response to acetylcholine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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