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Invitrogen
DAPK1 Polyclonal Antibody
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Product Details
PA5-83502
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DAPK1. Recombinant protein control fragment (Product #RP-102894).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QNAYLNGVGD FSVWEFSGNP VYFCCYDYFA ANDPTSIHVV VFSLEEPYEI QLNQVIFWLS FLKSLVPVEE PIAFGGKLKN PLQVVLVATH ADIMNVPRPA GGEFGYDKDT SLLKEIRNRF GNDLHISNKL FVLDAGA
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 96%.
Target Information
DAPK1 is a large, calmodulin-dependent kinase involved in gamma-interferon induced programmed cell death and is a potential tumor suppressor. DAPK1 is involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and authophagy. It regulates both type I apoptotic and type II autophagic cell death signal, depending on the cellular setting. Type I apoptotic cell death is caspase-dependent, type II authophagic cell death is caspase-independent. DAPK1 phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. It also phosphorylates TPM1, STX1A, PRKD1, BECN1, TSC2, RPS6, MYL9, and DAPK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAP kinase 1; Death-associated protein kinase 1; DKFZp781I035; OTTHUMP00000216193; unnamed protein product
Gene Aliases: DAPK; DAPK1; ROCO3
UniProt ID: (Human) P53355
Entrez Gene ID: (Human) 1612
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
GTP binding
kinase activity
transferase activity
syntaxin-1 binding
identical protein binding
protein serine kinase activity
defense response to tumor cell
regulation of response to tumor cell
regulation of translation
protein phosphorylation
apoptotic process
signal transduction
extrinsic apoptotic signaling pathway via death domain receptors
regulation of autophagy
positive regulation of autophagy
negative regulation of translation
intracellular signal transduction
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
protein autophosphorylation
cellular response to interferon-gamma
cellular response to hydroperoxide
apoptotic signaling pathway
positive regulation of autophagic cell death
regulation of N-methyl-D-aspartate selective glutamate receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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