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Invitrogen
NOD2 Polyclonal Antibody
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Product Details
PA5-83584
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NOD2. Recombinant protein control fragment (Product #RP-98741).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VWNKGTWACQ KLIAAAQEAQ ADSQSPKLHG CWDPHSLHPA RDLQSHRPAI VRRLHSHVEN MLDLAWERGF VSQYECDEIR LPI
Highest antigen sequence indentity to the following orthologs: Rat - 72%, Mouse - 73%.
Target Information
NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NOD 2; NOD-2; NOD-like receptor C2; NOD2 protein; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2; unnamed protein product
Gene Aliases: ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2; NOD2B; PSORAS1; YAOS
UniProt ID: (Human) Q9HC29
Entrez Gene ID: (Human) 64127
nucleotide binding
actin binding
protein binding
ATP binding
enzyme binding
protein kinase binding
Hsp70 protein binding
muramyl dipeptide binding
pattern recognition receptor activity
peptidoglycan binding
ubiquitin binding
anion binding
ADP binding
macromolecular complex binding
CARD domain binding
Hsp90 protein binding
carbohydrate derivative binding
temperature homeostasis
pattern recognition receptor signaling pathway
adaptive immune response
immune system process
positive regulation of dendritic cell antigen processing and presentation
positive regulation of cytokine production involved in immune response
positive regulation of dendritic cell cytokine production
positive regulation of type 2 immune response
autophagy
defense response
I-kappaB kinase/NF-kappaB signaling
response to nutrient
positive regulation of cell proliferation
detection of biotic stimulus
detection of bacterium
maintenance of gastrointestinal epithelium
regulation of appetite
response to muramyl dipeptide
detection of muramyl dipeptide
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-17 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
intracellular signal transduction
intestinal stem cell homeostasis
p38MAPK cascade
defense response to bacterium
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
innate immune response
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of gamma-delta T cell activation
host-mediated regulation of intestinal microbiota composition
positive regulation of epithelial cell proliferation
regulation of inflammatory response
positive regulation of B cell activation
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing 2 signaling pathway
protein K63-linked ubiquitination
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to muramyl dipeptide
protein linear polyubiquitination
antibacterial innate immune response
positive regulation of cytokine production involved in inflammatory response
positive regulation of NIK/NF-kappaB signaling
positive regulation of mitophagy
positive regulation of protein K63-linked ubiquitination
negative regulation of macrophage apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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