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Invitrogen

NOD2 Polyclonal Antibody

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View all (16) NOD2 antibodies

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NOD2 Polyclonal Antibody

Product Details

PA5-83584

Applications
Tested Dilution
Publications

Western Blot (WB)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NOD2. Recombinant protein control fragment (Product #RP-98741).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2790737

Product Specific Information

Immunogen sequence: VWNKGTWACQ KLIAAAQEAQ ADSQSPKLHG CWDPHSLHPA RDLQSHRPAI VRRLHSHVEN MLDLAWERGF VSQYECDEIR LPI

Highest antigen sequence indentity to the following orthologs: Rat - 72%, Mouse - 73%.

Target Information

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NOD 2; NOD-2; NOD-like receptor C2; NOD2 protein; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2; unnamed protein product

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Gene Aliases: ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2; NOD2B; PSORAS1; YAOS

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UniProt ID: (Human) Q9HC29

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Entrez Gene ID: (Human) 64127

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Function(s)
nucleotide binding actin binding protein binding ATP binding enzyme binding protein kinase binding Hsp70 protein binding muramyl dipeptide binding pattern recognition receptor activity peptidoglycan binding ubiquitin binding anion binding ADP binding macromolecular complex binding CARD domain binding Hsp90 protein binding carbohydrate derivative binding
Process(es)
temperature homeostasis pattern recognition receptor signaling pathway adaptive immune response immune system process positive regulation of dendritic cell antigen processing and presentation positive regulation of cytokine production involved in immune response positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response autophagy defense response I-kappaB kinase/NF-kappaB signaling response to nutrient positive regulation of cell proliferation detection of biotic stimulus detection of bacterium maintenance of gastrointestinal epithelium regulation of appetite response to muramyl dipeptide detection of muramyl dipeptide positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade intracellular signal transduction intestinal stem cell homeostasis p38MAPK cascade defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of gamma-delta T cell activation host-mediated regulation of intestinal microbiota composition positive regulation of epithelial cell proliferation regulation of inflammatory response positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked ubiquitination cellular response to lipopolysaccharide cellular response to peptidoglycan cellular response to muramyl dipeptide protein linear polyubiquitination antibacterial innate immune response positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of mitophagy positive regulation of protein K63-linked ubiquitination negative regulation of macrophage apoptotic process
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