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Invitrogen
U2AF2 Polyclonal Antibody
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Product Details
PA5-83667
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human U2AF2. Recombinant protein control fragment (Product #RP-98848).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PDSAHKLFIG GLPNYLNDDQ VKELLTSFGP LKAFNLVKDS ATGLSKGYAF CEYVDINVTD QAIAGLNGMQ LGDKKLLVQR ASVGAKNATL VS
Highest antigen sequence indentity to the following orthologs: Rat - 98%, Mouse - 100%.
Target Information
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hU2AF(65); hU2AF65; Splicing factor U2AF 65 kDa subunit; U2 (RNU2) small nuclear RNA auxiliary factor 2; U2 auxiliary factor 65 kDa subunit; U2 small nuclear ribonucleoprotein auxiliary factor (65kD); U2 snRNP auxiliary factor large subunit
Gene Aliases: U2AF2; U2AF65
UniProt ID: (Human) P26368
Entrez Gene ID: (Human) 11338
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
mRNA processing
RNA export from nucleus
mRNA export from nucleus
mRNA 3'-end processing
positive regulation of RNA splicing
negative regulation of mRNA splicing, via spliceosome
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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