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Invitrogen
PRAME Polyclonal Antibody
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FIGURE: 1 / 1
PRAME Antibody (PA5-83761)
Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of PRAME was observed specifically in U2OS cells and in SK-MEL-30 cells using anti-PRAME Polyclonal Antibody (Product #PA5-83761) in western blot. The relative expression levels of PRAME within each cell line is shown using RNA-Seq... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-83761
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRAME. Recombinant protein control fragment (Product #RP-88805).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LLLSHIHASS YISPEKEEQY IAQFTSQFLS LQCLQALYVD SLFFLRGRLD QLLRHVMNPL ETLSITNCRL SEGDVMHLSQ SPSVSQLSVL SLSGVMLTDV SPEPLQALLE RASATLQDLV FDECGI
Highest antigen sequence indentity to the following orthologs: Mouse - 55%, Rat - 55%.
Target Information
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Melanoma antigen preferentially expressed in tumors; OIP-4; Opa-interacting protein 4; Preferentially expressed antigen of melanoma
Gene Aliases: MAPE; OIP4; PRAME
Entrez Gene ID: (Human) 23532
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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