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Invitrogen

PABPC1 Polyclonal Antibody

View all (4) PABPC1 antibodies

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PABPC1 Polyclonal Antibody

Product Details

PA5-83772

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PABPC1. Recombinant protein control fragment (Product #RP-104389).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2790924

Product Specific Information

Immunogen sequence: PFSTMRPASS QVPRVMSTQR VANTST

Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.

Target Information

PABPC1b encodes a poly(A) binding protein|The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs|The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay|The gene is part of a small gene family including three protein-coding genes and several pseudogenes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase-1; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; CSNK1A1; cysteine protease; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45; PABP-1; pabpc1; poly A binding protein, cytoplasmic 1 b; poly(A) binding protein, cytoplasmic 2; Polyadenylate-binding protein 1; unnamed protein product; zgc:77608

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Gene Aliases: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PAB1; PABP; PABP1; PABPC1; PABPC2; PABPL1; PRO2975

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UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752, (Human) P11940

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Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011, (Human) 26986

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Function(s)
endopeptidase activity cysteine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process hydrolase activity enzyme binding kinase binding cytokine binding identical protein binding CARD domain binding nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity transferase activity protein serine kinase activity nucleic acid binding RNA binding mRNA binding mRNA 3'-UTR binding poly(A) binding poly(U) RNA binding translation activator activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter plasma membrane repair pattern recognition receptor signaling pathway proteolysis apoptotic process inflammatory response signal transduction osmosensory signaling pathway protein secretion protein autoprocessing protein catabolic process response to lipopolysaccharide positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production interleukin-18-mediated signaling pathway defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling icosanoid biosynthetic process ceramide biosynthetic process regulation of inflammatory response positive regulation of inflammatory response protein maturation defense response to virus protein poly-ADP-ribosylation pyroptosis interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to interferon-gamma cytokine precursor processing signaling receptor ligand precursor processing AIM2 inflammasome complex assembly pyroptotic cell death positive regulation of tumor necrosis factor-mediated signaling pathway autophagosome assembly protein phosphorylation Golgi organization cell surface receptor signaling pathway negative regulation of autophagy positive regulation of autophagy Wnt signaling pathway viral protein processing regulation of Wnt signaling pathway SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cellular response to nutrient levels cellular response to nutrient positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of Rho protein signal transduction TORC1 signaling proteasome-mediated ubiquitin-dependent protein catabolic process NLRP3 inflammasome complex assembly intermediate filament cytoskeleton organization cell division negative regulation of canonical Wnt signaling pathway negative regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly negative regulation of TORC1 signaling positive regulation of TORC1 signaling nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA splicing, via spliceosome mRNA processing RNA splicing gene silencing by RNA positive regulation of viral genome replication mRNA stabilization positive regulation of nuclear-transcribed mRNA poly(A) tail shortening CRD-mediated mRNA stabilization negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay positive regulation of cytoplasmic translation
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