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Invitrogen
MAPKAPK2 Polyclonal Antibody
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Product Details
PA5-83779
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MAPKAPK2. Recombinant protein control fragment (Product #RP-106093).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TMRVDYEQIK IKKIEDASNP LLLKRRKKAR ALEAAAL
Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 92%.
Target Information
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation. MAPKAPK2 encodes a member of the Ser/Thr protein kinase family. MAPKAPK2 is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for MAPKAPK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; mitogen-activated protein kinase-activated protein kinase 2
Gene Aliases: MAPKAP-K2; MAPKAPK2; MK-2; MK2
UniProt ID: (Human) P49137
Entrez Gene ID: (Human) 9261
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
calcium-dependent protein serine/threonine kinase activity
kinase activity
transferase activity
mitogen-activated protein kinase binding
protein serine kinase activity
MAPK cascade
toll-like receptor signaling pathway
leukotriene metabolic process
inflammatory response
cellular response to DNA damage stimulus
regulation of tumor necrosis factor-mediated signaling pathway
response to lipopolysaccharide
regulation of interleukin-6 production
regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor production
response to cytokine
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
p38MAPK cascade
regulation of mRNA stability
macropinocytosis
vascular endothelial growth factor receptor signaling pathway
mRNA stabilization
inner ear development
positive regulation of macrophage cytokine production
3'-UTR-mediated mRNA stabilization
regulation of cellular response to heat
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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