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Invitrogen
GPX4 Polyclonal Antibody
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Product Details
PA5-83862
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GPX4. Recombinant protein control fragment (Product #RP-104833).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NVKFDMFSKI CVNGDDAHPL WKWMKIQPKG KGILGNAIKW NFTKFLIDKN GCVVKRYGPM EEPLVIEKDL PHY
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 90%.
Target Information
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; Glutathione peroxidase 4; GPx-4; HGNC:4556; PHGPx; phospholipid hydroperoxidase; Phospholipid hydroperoxide glutathione peroxidase GPX4; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; selenoprotein GPX4; sperm nucleus glutathione peroxidase
Gene Aliases: GPx-4; GPX4; GSHPx-4; MCSP; PHGPx; SMDS; snGPx; snPHGPx
UniProt ID: (Human) P36969
Entrez Gene ID: (Human) 2879
chromatin organization
lipid metabolic process
phospholipid metabolic process
apoptotic process
response to oxidative stress
spermatogenesis
dendrite development
arachidonic acid metabolic process
lipoxygenase pathway
cerebellum development
response to estradiol
response to lipopolysaccharide
multicellular organism growth
long-chain fatty acid biosynthetic process
protein polymerization
cellular oxidant detoxification
negative regulation of ferroptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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