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Invitrogen
Lamin B2 Polyclonal Antibody
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FIGURE: 1 / 6
Lamin B2 Antibody (PA5-83887) in IHC (P)
Immunohistochemistry analysis of Lamin B2 in human cerebral cortex, fallopian tube, kidney and testis. Samples were incubated with Lamin B2 polyclonal antibody (Product # PA5-83887). Shows similar protein distribution across tissues to independent Lamin B2 antibody (Product # PA5-84554) (B).
Product Details
PA5-83887
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LMNB2. Recombinant protein control fragment (Product #RP-104279).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DEVNKSAKKR EGELTVAQGR VKDLESLFHR SEVELAAALS DKRGLESDVA ELRAQLAKAE DGHAVAKKQL EKETLM
Highest antigen sequence indentity to the following orthologs: Rat - 87%, Mouse - 89%.
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: lamin B3; Lamin-B2; MGC2721
Gene Aliases: EPM9; LAMB2; LMN2; LMNB2
UniProt ID: (Human) Q03252
Entrez Gene ID: (Human) 84823
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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