Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
PKC beta Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-83906
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRKCB. Recombinant protein control fragment (Product #RP-103020).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EKLERKEIQP PYKPKARDKR DTSNFDKEFT RQPVELTPTD KLFIMNLDQN EFAGFSYTNP EFVIN
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: PKC-B; Protein kinase C beta type; protein kinase C, beta 1 polypeptide
Gene Aliases: PKC-beta; PKCB; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P05771
Entrez Gene ID: (Human) 5579
chromatin binding
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein kinase C binding
calcium channel regulator activity
protein binding
ATP binding
zinc ion binding
ligand-dependent nuclear receptor transcription coactivator activity
histone kinase activity (H3-T6 specific)
histone binding
androgen receptor binding
non-receptor serine/threonine protein kinase
response to hypoxia
adaptive immune response
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
calcium ion transport
cellular calcium ion homeostasis
apoptotic process
mitotic nuclear envelope disassembly
signal transduction
negative regulation of glucose transport
peptidyl-serine phosphorylation
platelet activation
positive regulation of vascular endothelial growth factor receptor signaling pathway
histone H3-T6 phosphorylation
intracellular signal transduction
B cell activation
lipoprotein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
negative regulation of insulin receptor signaling pathway
B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
cellular response to carbohydrate stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support