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Invitrogen
LFG Polyclonal Antibody
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FIGURE: 1 / 7
LFG Antibody (PA5-83927) in IHC (P)
Immunohistochemistry analysis of LFG in human cerebral cortex, kidney, liver and lymph node. Samples were incubated with LFG polyclonal antibody (Product # PA5-83927). Shows similar protein distribution across tissues to independent LFG antibody (Product # PA5-82634) (B).
Product Details
PA5-83927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FAIM2. Recombinant protein control fragment (Product #RP-92045).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PTAVPLHPSW AYVDPSSSSS YDNGFPTGDH ELFTTFSWDD QKVRRVFVRK V
Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 82%.
Target Information
LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn't have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn't protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fas apoptotic inhibitory molecule 2; Neural membrane protein 35; protein lifeguard; Protein lifeguard 2; Transmembrane BAX inhibitor motif-containing protein 2
Gene Aliases: FAIM2; KIAA0950; LFG; LFG2; NGP35; NMP35; TMBIM2
UniProt ID: (Human) Q9BWQ8
Entrez Gene ID: (Human) 23017
response to ischemia
apoptotic process
cerebellum development
cerebellar Purkinje cell layer development
cerebellar granular layer development
cerebellar Purkinje cell differentiation
negative regulation of apoptotic process
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
negative regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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