Search
Invitrogen
Dectin 1 (soluble) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-83996
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CLEC7A. Recombinant protein control fragment (Product #RP-104894).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DSSNELGFIV KQVSSQPDNS FWIGLSRPQT EVPWLWEDGS TFSSNLFQIR TTATQENPSP NCVWIHVSVI YDQLCSVPSY SICEKKFS
Highest antigen sequence indentity to the following orthologs: Mouse - 35%, Rat - 56%.
Target Information
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beta-glucan receptor; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin BGRA; C-type lectin BGRB; C-type lectin BGRC; C-type lectin BGRD; C-type lectin BGRE; C-type lectin BGRF; C-type lectin BGRG; C-type lectin BGRH; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; CD369; DC-associated C-type lectin 1; dectin-1; dectin-1 beta; dectin-1; C-type lectin receptor; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; unnamed protein product
Gene Aliases: BGR; CANDF4; CD369; CLEC7A; CLECSF12; DECTIN1; SCARE2; UNQ539/PRO1082
UniProt ID: (Human) Q9BXN2
Entrez Gene ID: (Human) 64581
cell activation
response to yeast
detection of yeast
stimulatory C-type lectin receptor signaling pathway
immune system process
positive regulation of cytokine production involved in immune response
positive regulation of dendritic cell cytokine production
cell surface pattern recognition receptor signaling pathway
phagocytosis, recognition
inflammatory response
cell recognition
positive regulation of cell proliferation
carbohydrate mediated signaling
positive regulation of gene expression
detection of fungus
positive regulation of cell migration
positive regulation of protein complex assembly
detection of molecule of fungal origin
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-2 production
positive regulation of interleukin-23 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of superoxide anion generation
T cell activation
defense response to protozoan
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
innate immune response
leukocyte activation
positive regulation of nitric oxide biosynthetic process
positive regulation of phagocytosis
positive regulation of calcium-mediated signaling
positive regulation of lymphocyte activation
positive regulation of respiratory burst
antifungal innate immune response
regulation of calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade
cellular response to molecule of fungal origin
positive regulation of monocyte chemotactic protein-1 production
positive regulation of wound healing
apoptotic signaling pathway
positive regulation of cytokine production involved in inflammatory response
positive regulation of cell maturation
positive regulation of T-helper 17 type immune response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support