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Invitrogen
RYBP Polyclonal Antibody
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Product Details
PA5-84149
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RYBP. Recombinant protein control fragment (Product #RP-100972).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KQDKEKPEKD KEISPSVTKK NTNKKTKPKS DILKDPPSEA NSIQSANATT KTSETNHTSR P
Highest antigen sequence indentity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AAP-1; APAP-1; Apoptin-associating protein 1; Death effector domain-associated factor; DED-associated factor; RING1 and YY1-binding protein; ring1 interactor RYBP; YAF2 homolog; DEDAF; RYBP; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1
Gene Aliases: AAP1; APAP-1; DEDAF; RYBP; YEAF1
UniProt ID: (Human) Q8N488
Entrez Gene ID: (Human) 23429
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
regulation of transcription, DNA-templated
apoptotic process
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
positive regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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