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Invitrogen
PDE3B Polyclonal Antibody
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Product Details
PA5-84277
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDE3B. Recombinant protein control fragment (Product #RP-106687).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LSPVNSSNHG PVSTGSLTNR SPIEFPDTAD FLNKPSVILQ RSLGNAPNTP DFYQQLRNSD SNLCNSCGHQ MLKYVSTSES DGTDCCSGKS GEEENIFSKE SFKLMETQQE EETEKKDSRK LFQEGDKWLT EEAQSEQQTN IEQEVS
Highest antigen sequence indentity to the following orthologs: Mouse - 66%, Rat - 63%.
Target Information
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CGI-PDE B; CGIP1; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; cyclic nucleotide phosphodiesterase; phosphodiesterase 3B, cGMP-inhibited
Gene Aliases: cGIPDE1; HcGIP1; PDE3B
UniProt ID: (Human) Q13370
Entrez Gene ID: (Human) 5140
angiogenesis
negative regulation of cell adhesion
signal transduction
G-protein coupled receptor signaling pathway
insulin receptor signaling pathway
negative regulation of angiogenesis
negative regulation of cell adhesion mediated by integrin
regulation of angiogenesis
negative regulation of lipid catabolic process
regulation of protein kinase B signaling
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of cAMP/PKA signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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