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Invitrogen
PDX1 Polyclonal Antibody
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Product Details
PA5-84405
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PDX1. Recombinant protein control fragment (Product #RP-103346).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DISPYEVPPL ADDPAVAHLH HHLPAQLALP HPPAGPFPEG AEPGVLEEPN RVQLPFPWMK STKA
Highest antigen sequence indentity to the following orthologs: Mouse - 88%, Rat - 84%.
Target Information
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DLDBP; E3BP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1
Gene Aliases: GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1
UniProt ID: (Human) P52945
Entrez Gene ID: (Human) 3651
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
macromolecular complex binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
liver development
type B pancreatic cell differentiation
glucose metabolic process
generation of precursor metabolites and energy
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
response to glucose
organ morphogenesis
response to iron(II) ion
response to chlorate
glucose mediated signaling pathway
regulation of gene expression
morphogenesis of embryonic epithelium
insulin secretion
cell differentiation
pancreas development
exocrine pancreas development
endocrine pancreas development
organ regeneration
response to nutrient levels
positive regulation of insulin secretion
response to vitamin
response to lipid
response to cytokine
response to nicotine
positive regulation of insulin secretion involved in cellular response to glucose stimulus
enteroendocrine cell differentiation
regulation of cell proliferation
glucose homeostasis
response to leucine
response to alkaloid
type B pancreatic cell proliferation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
stem cell differentiation
epithelial cell proliferation
negative regulation of epithelial cell proliferation
response to glucocorticoid
transdifferentiation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
response to fatty acid
type B pancreatic cell apoptotic process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
cellular response to acadesine
positive regulation of type B pancreatic cell proliferation
negative regulation of type B pancreatic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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