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Invitrogen
HES4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-84551
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HES4. Recombinant protein control fragment (Product #RP-105231).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DTPGKPSASP MAGAPASASR TPDK
Highest antigen sequence indentity to the following orthologs: Mouse - 54%, Rat - 54%.
Target Information
HES4, or Hes Family BHLH Transcription Factor 4, is a gene located on chromosome 1p36.31, encoding a basic helix-loop-helix (bHLH) transcription factor that plays a role in the Notch signaling pathway. This pathway is integral to cell differentiation, proliferation, and apoptotic processes, especially during embryonic development and tissue homeostasis. HES4 acts as a transcriptional repressor, regulating the expression of genes responsible for maintaining stem cell populations and inhibiting premature differentiation. While its exact biological roles are still being elucidated, studies suggest HES4 influences neurogenesis and myogenesis by modulating the timing of differentiation events within progenitor cells. The dysregulation of HES4 can impact normal developmental processes, potentially contributing to pathologies such as cancer and developmental disorders due to its control over cellular growth and differentiation pathways. Research into HES4 continues to advance understanding of its functions within the context of Notch signaling and its implications for disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLH factor Hes4; class B basic helix-loop-helix protein 42; hairy and enhancer of split 4; hHES4
Gene Aliases: bHLHb42
UniProt ID: (Human) Q9HCC6
Entrez Gene ID: (Human) 57801
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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