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Invitrogen
TCF3 Polyclonal Antibody
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Product Details
PA5-84553
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TCF3. Recombinant protein control fragment (Product #RP-103451).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LAGSTSLMHN HAALPSQPGT LPDLSRPPDS YSGLGRAGA
Highest antigen sequence indentity to the following orthologs: Mouse - 75%, Rat - 73%.
Target Information
TCF3 (E2A) is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHb21; Class B basic helix-loop-helix protein 21; e12 protein; E2A-HLF fusion transcript protein; helix-loop-helix protein HE47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; MGC129647; MGC129648; negative vitamin D response element-binding protein; NOL1-TCF3 fusion; TCF-3; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcription factor E2-alpha; transcription factor E2A; Transcription factor ITF-1; VDR interacting repressor; vitamin D receptor-interacting repressor
Gene Aliases: AGM8; AGM8A; AGM8B; BHLHB21; E2A; E47; ITF1; p75; TCF-3; TCF3; VDIR
UniProt ID: (Human) P15923
Entrez Gene ID: (Human) 6929
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
mitogen-activated protein kinase kinase kinase binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
vitamin D response element binding
E-box binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
B cell lineage commitment
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
cell differentiation
B cell differentiation
positive regulation of B cell proliferation
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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