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Invitrogen

ITGB1BP1 Polyclonal Antibody

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ITGB1BP1 Polyclonal Antibody

Product Details

PA5-84755

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ITGB1BP1. Recombinant protein control fragment (Product #RP-108528).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Amount

5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2791905

Product Specific Information

Immunogen sequence: VSKYGIKVST SDQYDVLHRH ALYLIIRMVC YDDGLGAGKS LLALKTTDAS NEEYSLWVYQ CNSLEQAQAI CKVLSTAFDS VLT

Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.

Target Information

Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternatively spliced variant of Icap-1a; doesn't bind b1 integrin; bodenin; DKFZp686K08158; ICAP-1; Integrin beta-1-binding protein 1; Integrin cytoplasmic domain-associated protein 1; integrin cytoplasmic domain-associated protein 1-alpha; integrin cytoplasmic domain-associated protein 1-beta; ITGB1BP1; unnamed protein product

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Gene Aliases: ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1; ICAP1A; ICAP1B; ITGB1BP1

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UniProt ID: (Human) O14713

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Entrez Gene ID: (Human) 9270

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Function(s)
GDP-dissociation inhibitor activity integrin binding protein binding kinase binding protein kinase binding
Process(es)
angiogenesis blood vessel endothelial cell proliferation involved in sprouting angiogenesis negative regulation of protein kinase activity negative regulation of cell adhesion involved in substrate-bound cell migration cell adhesion cell-matrix adhesion Notch signaling pathway integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation regulation of signal transduction positive regulation of endothelial cell migration negative regulation of fibroblast migration cell migration cell differentiation negative regulation of cell migration biomineral tissue development negative regulation of protein binding activation of protein kinase B activity integrin activation regulation of cell adhesion mediated by integrin tube formation intracellular signal transduction cellular response to vascular endothelial growth factor stimulus regulation of GTPase activity receptor clustering cellular response to fibroblast growth factor stimulus positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter myoblast migration positive regulation of stress fiber assembly positive regulation of cell division positive regulation of focal adhesion assembly negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of ERK1 and ERK2 cascade protein localization to membrane protein localization to plasma membrane negative regulation of cell migration involved in sprouting angiogenesis regulation of protein targeting to membrane positive regulation of protein targeting to membrane negative regulation of protein targeting to membrane regulation of blood vessel diameter negative regulation of substrate adhesion-dependent cell spreading regulation of integrin-mediated signaling pathway
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