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Invitrogen
CD150 Polyclonal Antibody
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Product Details
PA5-84809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLAMF1. Recombinant protein control fragment (Product #RP-108245).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KVLLPLTYER INKSMNKSIH IVVTMAKSLE NSVENKIVSL DPSEAGPPRY LGDRYKFYLE NLTLGIRESR KE
Highest antigen sequence indentity to the following orthologs: Rat - 49%, Mouse - 48%.
Target Information
CD150, also known as SLAM (Signaling Lymphocyte Activation Molecule), is a member of the immunoglobulin gene superfamily and plays a crucial role in T cell stimulation and immune cell interactions. It is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells. CD150 expression is rapidly upregulated upon activation, particularly on naive T cells, Th1 cells, and activated B cells, which express the membrane-bound, soluble, and cytoplasmic isoforms of SLAM. In T cells, signaling through SLAM induces proliferation and enhances the interferon-gamma response. SLAM is also involved in adhesion between T cells and antigen-presenting cells, facilitating immune cell interactions. Homophilic SLAM-SLAM binding during B to B and B to T cell interactions is suggested to enhance the expansion and differentiation of activated B cells. CD150 serves as a receptor for the measles virus and acts as a co-activator on T and B cells. It interacts with SH2D1A and PTPN11 via its cytoplasmic domain, playing a role in signal transduction. Mutations in the CD150 gene may be associated with X-linked lymphoproliferative disease (XLP), highlighting its importance in immune regulation and disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD150; CD150 antigen; CDw150; IPO-3; Signaling lymphocytic activation molecule; SLAM family member 1
Gene Aliases: CD150; CDw150; SLAM; SLAMF1
UniProt ID: (Human) Q13291
Entrez Gene ID: (Human) 6504
natural killer cell differentiation
natural killer cell proliferation
myeloid dendritic cell activation involved in immune response
negative regulation of T cell cytokine production
phagocytosis
cell adhesion
signal transduction
positive regulation of cell proliferation
regulation of vesicle fusion
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
T-helper 1 cell cytokine production
positive regulation of activated T cell proliferation
innate immune response
positive regulation of JNK cascade
viral entry into host cell
regulation of catalytic activity
positive regulation of ERK1 and ERK2 cascade
negative regulation of interferon-gamma secretion
positive regulation of interferon-gamma secretion
negative regulation of CD40 signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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