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Immunogen sequence: GITSDSLVAE TSITSVEELA KKMESVKSCL SPKEREQVTA TPRIAKAEQH NYPGIKLQIG PIPRINGMPE VQDMKFITPV RRSSRIERAV SRYPEMLQEH DLVVAS
Highest antigen sequence indentity to the following orthologs: Mouse - 64%, Rat - 63%.
The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cytoskeleton associated protein 2-like; Cytoskeleton-associated protein 2-like; FLJ40629; Radial fiber and mitotic spindle protein; Radmis
Gene Aliases: CKAP2L
UniProt ID: (Human) Q8IYA6
Entrez Gene ID: (Human) 150468
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