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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: VLESELVQRI QTLSQLLLNL QAVIAHQDSY VETQRAAIQE REKQFRLQST RGNLLLEQER QRNFEKQR
Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 91%.
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 114 kDa Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; Rho guanine nucleotide exchange factor 18; SA-RhoGEF; Septin-associated RhoGEF
Gene Aliases: ARHGEF18; KIAA0521
Entrez Gene ID: (Human) 23370
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