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Invitrogen
CHMP3 Polyclonal Antibody
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Product Details
PA5-84924
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CHMP3. Recombinant protein control fragment (Product #RP-108612).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VNEWSLKIRK EMRVVDRQIR DIQREEEKVK RSVKDAAKKG QKDVCIVLAK EMIRSRKA
Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 97%.
Target Information
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 25.1 protein; CGI-149; Charged multivesicular body protein 3; CHMP family, member 3; Chromatin-modifying protein 3; hVps24; NEDF; Neuroendocrine differentiation factor; unnamed protein product; vacuolar protein sorting 24 homolog; Vacuolar protein sorting-associated protein 24
Gene Aliases: CGI-149; CGI149; CHMP3; NEDF; VPS24
UniProt ID: (Human) Q9Y3E7
Entrez Gene ID: (Human) 51652
plasma membrane repair
autophagy
apoptotic process
nucleus organization
vacuolar transport
mitotic metaphase plate congression
endosome to lysosome transport
regulation of centrosome duplication
protein transport
macroautophagy
viral release from host cell
nuclear envelope reassembly
positive regulation of cytokinesis
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
negative regulation by host of viral release from host cell
late endosome to vacuole transport
viral budding from plasma membrane
regulation of endosome size
protein polymerization
cell division
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
regulation of exosomal secretion
regulation of early endosome to late endosome transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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