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Invitrogen
MAEL Polyclonal Antibody
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Product Details
PA5-85064
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MAEL. Recombinant protein control fragment (Product #RP-94271).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PVFTPLRRPG MLVPKQNVSP PDMSALSLKG DQALLGGIFY FLNIFSHGEL PPHCEQRFLP CEIGCVKYSL QEGIMADFH
Highest antigen sequence indentity to the following orthologs: Rat - 90%, Mouse - 90%.
Target Information
The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cancer/testis antigen 128; maelstrom homolog; Protein maelstrom homolog; RP11-102C16.1; spermatogenesis associated 35; testicular tissue protein Li 116; unnamed protein product
Gene Aliases: CT128; MAEL; SPATA35
UniProt ID: (Human) Q96JY0
Entrez Gene ID: (Human) 84944
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
apoptotic process
cellular response to DNA damage stimulus
synapsis
male meiosis
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
fertilization
gene expression
negative regulation of gene expression
cell differentiation
gene silencing by RNA
piRNA metabolic process
ectopic germ cell programmed cell death
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
regulation of organ growth
negative regulation of developmental process
meiotic cell cycle
regulation of gene silencing by miRNA
transposable element silencing by piRNA-mediated DNA methylation
negative regulation of reproductive process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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