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Invitrogen
TBR1 Polyclonal Antibody
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FIGURE: 1 / 6
TBR1 Antibody (PA5-85065) in IHC (P)
Immunohistochemistry analysis of TBR1 in human cerebral cortex, liver, pancreas and skeletal muscle. Samples were incubated with TBR1 polyclonal antibody (Product # PA5-85065). Shows similar protein distribution across tissues to independent TBR1 antibody (Product # PA5-85066) (B).
Product Details
PA5-85065
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TBR1. Recombinant protein control fragment (Product #RP-106332).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LEHCLSPSIM LSKKFLNVSS SYPHSGGSEL VLHDHPIIST TDNLERSSPL KKITRGMTNQ SDTDNFPDSK DSPGDVQRSK LSPVLDGVSE LRHSFD
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: T-box brain protein 1; T-box, brain 1; T-brain-1; TES-56; unnamed protein product
Gene Aliases: AUTS5; IDDAS; TBR-1; TBR1; TES-56
UniProt ID: (Human) Q16650
Entrez Gene ID: (Human) 10716
conditioned taste aversion
cell fate specification
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
brain development
specification of organ identity
gene expression
regulation of gene expression
regulation of neuron projection development
amygdala development
commitment of neuronal cell to specific neuron type in forebrain
cerebral cortex development
neuron differentiation
hindbrain development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of axon guidance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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