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Invitrogen
VPS4B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-100700
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human VPS4B(Accession O75351), corresponding to amino acid residues N78-R128.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total VPS4B.
Target Information
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell migration-inducing 1; cell migration-inducing gene 1 protein; MIG1; suppressor of K(+) transport growth defect 1; suppressor of K+ transport defect 1; unnamed protein product; vacuolar protein sorting 4B
Gene Aliases: 8030489C12Rik; DTDP1B; MIG1; SKD1; SKD1B; VPS4-2
UniProt ID: (Human) O75351, (Mouse) P46467
Entrez Gene ID: (Human) 9525, (Mouse) 20479, (Rat) 360834
angiogenesis
plasma membrane repair
potassium ion transport
autophagy
nucleus organization
endosome organization
vacuole organization
vacuolar transport
mitotic metaphase plate congression
central nervous system development
regulation of centrosome duplication
positive regulation of G2/M transition of mitotic cell cycle
endosomal transport
cholesterol transport
nuclear envelope reassembly
endosome transport via multivesicular body sorting pathway
endosome to lysosome transport via multivesicular body sorting pathway
response to lipid
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding from plasma membrane
protein depolymerization
canonical Wnt signaling pathway
establishment of blood-brain barrier
late endosomal microautophagy
late endosome to lysosome transport via multivesicular body sorting pathway
midbody abscission
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
negative regulation of exosomal secretion
positive regulation of exosomal secretion
positive regulation of centriole elongation
ESCRT III complex disassembly
biological_process
lysosomal transport
regulation of G2/M transition of mitotic cell cycle
macroautophagy
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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