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Invitrogen
Phospho-EphA2 (Tyr772) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101032
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EPHA2(Accession P29317), corresponding to amino acid residues around phosphorylated Tyr772.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of EPHA2 only when phosphorylated at Tyr772.
Target Information
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epithelial cell receptor protein tyrosine kinase; tyrosine-protein kinase receptor ECK; unnamed protein product
Gene Aliases: ARCC2; CTPA; CTPP1; CTRCT6; ECK
UniProt ID: (Human) P29317
Entrez Gene ID: (Human) 1969
angiogenesis
osteoblast differentiation
response to stress
transmembrane receptor protein tyrosine kinase signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of lamellipodium assembly
cell migration
regulation of cell adhesion
keratinocyte differentiation
osteoclast differentiation
regulation of cell migration
positive regulation of cell migration
epithelial cell differentiation
mammary gland epithelial cell proliferation
negative regulation of cell adhesion mediated by integrin
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
cAMP metabolic process
bone remodeling
ephrin receptor signaling pathway
animal organ development
cell motility
cell chemotaxis
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
regulation of ERK1 and ERK2 cascade
response to growth factor
protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
positive regulation of bicellular tight junction assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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