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Invitrogen
AMPK gamma-1,2,3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101131
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRKAG1(Accession P54619), corresponding to amino acid residues K58-E108.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PRKAG1/2/3.
Target Information
The 5-AMP activated protein kinase (AMPK), a member of the SNF1 (sucrose non fermentor) kinase family, is a heterotrimeric protein comprise of alpha (63 kDa), beta (30 kDa) and gamma (38 kDa) subunits. The alpha subunit is the catalytic subunit, while beta and gamma are non catalytic subunits (although they have been found to interact with the active subunit in liver). AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA as well as cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase. AMPK is activated by AMP and can be also regulated by treatment with purified protein phosphatase in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-AMP-activated protein kinase, gamma-1 subunit; 5'-AMP-activated protein kinase, gamma-3 subunit; adenosine monophosphate-activated protein kinase gamma 2-subunit; AMP-activated protein kinase gamma 3 subunit; AMP-activated protein kinase gamma subunit; AMP-activated protein kinase gamma2 subunit; AMP-activated protein kinase, noncatalytic gamma-1 subunit; ampk gamma; AMPK gamma 2; AMPK gamma-1 chain; AMPK gamma-2 chain; AMPK gamma-3 chain; AMPK gamma1; AMPK gamma3; AMPK subunit gamma-1; AMPK subunit gamma-2; AMPK subunit gamma-3; AMPK- gamma1; AMPK- gamma2; AMPK- gamma3; AMPKg; AMPKG3; epididymis secretory sperm binding protein; Protein kinase AMP-activated gamma; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit; unnamed protein product
Gene Aliases: 2410051C13Rik; AAKG; AAKG2; Amkg3; AMPKG; AMPKG3; AMPKg3L; AMPKg3S; CMH6; GSDH; H91620p; Prkaac; Prkga1; SMGMQTL; WPWS
UniProt ID: (Human) P54619, (Human) Q9UGJ0, (Human) Q9UGI9, (Rat) P80385, (Mouse) O54950, (Mouse) Q91WG5, (Mouse) Q8BGM7
Entrez Gene ID: (Human) 5571, (Human) 51422, (Human) 53632, (Rat) 25520, (Mouse) 19082, (Rat) 373545, (Mouse) 108099, (Rat) 301518, (Mouse) 241113
AMP-activated protein kinase activity
cAMP-dependent protein kinase activity
protein binding
ATP binding
cAMP-dependent protein kinase regulator activity
AMP binding
protein kinase regulator activity
protein kinase binding
ADP binding
macromolecular complex binding
cAMP-dependent protein kinase inhibitor activity
phosphorylase kinase regulator activity
protein kinase activator activity
regulation of glycolytic process
response to muscle activity involved in regulation of muscle adaptation
cellular response to nutrient levels
cellular response to glucose starvation
negative regulation of glycogen biosynthetic process
positive regulation of gluconeogenesis
regulation of catalytic activity
intracellular signal transduction
regulation of cell cycle
glycogen metabolic process
regulation of fatty acid metabolic process
protein phosphorylation
signal transduction
spermatogenesis
ATP biosynthetic process
sterol biosynthetic process
regulation of fatty acid oxidation
regulation of glucose import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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