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Invitrogen
DLX5 Polyclonal Antibody
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FIGURE: 1 / 4
DLX5 Antibody (PA5-101134) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded DLX5 in mouse heart tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with DLX5 polyclonal antibody (Product # PA5-101134) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DLX5(Accession P56178), corresponding to amino acid residues G106-F156.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DLX5.
Target Information
This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: distal-less homeo box 5; DLX-3; homeobox protein DLX-3; split hand/foot malformation type 1 with sensorineural hearing loss; unnamed protein product
Gene Aliases: RDLX; SHFM1; SHFM1D
UniProt ID: (Human) P56178, (Rat) P50575, (Mouse) P70396
Entrez Gene ID: (Human) 1749, (Rat) 25431, (Mouse) 13395
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
HMG box domain binding
sequence-specific double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
osteoblast differentiation
endochondral ossification
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
axonogenesis
axon guidance
cell proliferation
positive regulation of gene expression
olfactory bulb interneuron differentiation
cell differentiation
embryonic limb morphogenesis
BMP signaling pathway
epithelial cell differentiation
cellular response to zinc ion starvation
inner ear morphogenesis
ear development
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
anatomical structure formation involved in morphogenesis
embryonic skeletal system development
positive regulation of epithelial cell proliferation
palate development
olfactory pit development
head development
face morphogenesis
bone morphogenesis
positive regulation of canonical Wnt signaling pathway
interneuron axon guidance
skeletal system development
nervous system development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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